Locations Main Campus: Chesterfield, MO 63017   |   Locations
314-434-1500 314-434-1500   |   Contact Us

Complementary and Alternative Medicine


E-mail Form
Email Results


Diuretics - potassium-sparing diuretics

Potassium-sparing diuretics include:

  • Amiloride (Midamor)
  • Spironolactone (Aldactone)
  • Triamterene (Dyrenium)

Potassium-sparing diuretics and thiazide diuretics may sometimes be used together. Diuretic combinations include:

  • Hydrocholorothiazide/triamterene (Maxzide, Dyazide)
  • Hydrochlorothiazide/ spironolactone (Aldactazide)
  • Amiloride/ hydrochlorothiazide (Moduretic)

Depletions from potassium-sparing diuretics are discussed in this article. If you are taking any of these combinations, you may also want to consult the thiazide diuretics depletion article .



Taking triamterene may deplete vitamin B9.

Vitamin B9 (Folic Acid)

Low levels of folic acid in the body may be linked to:

  • Anemia
  • Heart disease
  • Birth defects

Symptoms may include:

  • Weakness
  • Mouth sores
  • Swollen tongue
  • Depression
  • Poor growth

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.

Factors that affect the level of nutrients are:

  • Your medical history
  • Diet
  • Lifestyle
  • How long you have been taking the medicine

Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.

Supporting Research

Gold Standard Drug Database. Drug Monograph: Triamterene, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-626 . Accessed July 5, 2016.

Gold Standard Drug Database. Drug Monograph: Hydrochlorothiazide, HCTZ; Spironolactone, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1085 . Accessed July 19, 2016.

Gold Standard Drug Database. Drug Monograph: Hydrochlorothiazide, HCTZ; Triamterene, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1087 . Accessed July 19, 2016.

Gold Standard Drug Database. Drug Monograph: Amiloride; Hydrochlorothiazide, HCTZ, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-863 . Accessed July 19, 2016.

Hoorn EJ, Wilcox CS, Ellison DH. Diuretics. In: Skorecki K, Chertow GM, Marsden PA, Yu ASL, Taal MW, eds. Brenner and Rector's The Kidney . 10th ed. Philadelphia, PA: Elsevier; 2016:chap 51.

Sachdev HPS, Shah D. Vitamin B complex deficiencies and excess. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 49.

Shenkin A, Roberts NB. Vitamins and trace elements. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics . 5th ed. St. Louis, MO: Elsevier Saunders; 2012:chap 31.

        The Basics


          Advanced Study





          Review Date: 9/19/2016  

          Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network. Also reviewed by the A.D.A.M. Editorial team.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

          A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.

          Content is best viewed in IE9 or above, Firefox and Google Chrome browser.