Evening primrose is a wildflower that grows throughout the U.S. Although Native Americans used the seeds for food and made poultices from the whole plant to heal bruises, evening primrose oil (EPO) has only recently been used as medicine. European settlers took the root back to England and Germany, where it was eaten as food.
Evening primrose oil is found in the plant's seeds and is high in the essential fatty acid gamma-linolenic acid (GLA). Essential fatty acids -- such as omega-6, found in EPO, and omega-3, found in fish oil -- are used as building blocks for a number of molecules in the body. Your body needs a balance of omega-6 and omega-3 fatty acids for good health. In addition to evening primrose oil, GLA is found in borage oil and black currant oil.
Today, EPO is used to relieve PMS symptoms and some arthritis-related conditions, although there is not a lot of scientific evidence about using EPO for those conditions. The strongest evidence for EPO is for treating eczema.
EPO is used mostly to relieve the itchiness causes by certain skin conditions, such as eczema and dermatitis. It is also used to ease breast tenderness from premenstrual syndrome (PMS) or other causes. Some of the uses for EPO include:
Eczema symptoms include redness and scaling in addition to itching. More than 30 human studies report the benefits of EPO for eczema and dermatitis. A study of 1,207 patients found that EPO helped relieve symptoms from skin conditions, including itching, crusting, edema (fluid, swelling), and redness. EPO can be used in children and adults with skin conditions.
Premenstrual syndrome (PMS)
Many women throughout the world take EPO to reduce symptoms of PMS, although there isn’t any real scientific evidence that it works. In one review of 10 studies that used EPO to treat PMS, only two were well designed. Both of those studies found that EPO had no effect on PMS symptoms. Better studies are needed to know for sure.
Rheumatoid arthritis (RA)
Although a few studies have found that people with RA who took EPO felt better, the studies were hampered by poor design and high drop-out rates. Also, there wasn’t any evidence that taking EPO actually helped slow down the joint damage that happens with RA. Rheumatoid arthritis should be treated with conventional medications, to slow down or stop permanent joint damage.
One small study suggests that taking EPO may help reduce symptoms in some people with Raynaud’s phenomenon. But the study found no difference in hand temperature between people who took EPO and those who took placebo. More studies are needed.
Diabetic peripheral neuropathy
Diabetic peripheral neuropathy is a nerve condition where people with diabetes have numbness, tingling, pain, burning, or lack of sensation in their feet and legs. Two studies have found that GLA may help reduce symptoms of diabetic neuropathy.
Although there is not a lot of scientific evidence, EPO is widely used to treat breast pain (mastalgia) in a number of European countries. A few studies have found that EPO seemed to help, but they have not been well-designed studies. Other studies show no benefit.
Although EPO has gotten popular for treating hot flashes, there is no scientific evidence that it actually helps.
If you are currently being treated with any of the following medications, you should not use EPO without first talking to your health care provider.
Blood-thinning medications (anticoagulants) -- EPO may raise the risk of bleeding, especially if you take blood-thinners such as aspirin, warfarin (Coumadin), and clopidogrel (Plavix).
Blood pressure medications -- EPO may lower blood pressure in some people, although researchers aren’t sure. If you take medications to treat high blood pressure, ask your doctor before taking EPO.
Phenothizines -- People who take a class of medications called phenothiazines to treat schizophrenia should not take EPO because it may increase the risk of seizures.
Medications to control seizures -- EPO may lower the threshold for seizures, so people who are prone to seizures should not take it.
Antidepressants -- It’s possible, although researchers aren’t sure, that EPO may interact with some antidepressants, including selective serotonin uptake inhibitors such as:
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Sertraline (Zoloft)
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