Chesterfield, MO., JULY 25, 2025 - St. Luke’s is proud to announce it has been recognized as one of the 2025–2026 Best Hospitals by U.S. News & World Report, affirming its commitment to delivering high-quality, patient-centered care.
In the most recent rankings, St. Luke’s ranked No. 5 in the state of Missouri and was named a Best Regional Hospital, placing it among an elite group of healthcare institutions nationwide. U.S. News recognized only 504 Best Regional Hospitals across 49 states and 95 metro areas based on exceptional performance and patient outcomes.
St. Luke’s earned High Performing ratings in 18 procedures and conditions, a distinction that highlights the hospital’s superior clinical care across multiple specialties:
- Abdominal aortic aneurysm repair
- Aortic valve surgery
- Back surgery (spinal fusion)
- Colon cancer surgery
- Diabetes
- Heart arrhythmia
- Heart attack
- Heart bypass surgery
- Heart failure
- Hip replacement
- Kidney failure
- Knee replacement
- Leukemia, lymphoma & myeloma
- Lung cancer surgery
- Pacemaker implantation
- Pneumonia
- Stroke
- Transcatheter aortic valve replacement (TAVR)
“We are incredibly proud to be named one of the Best Hospitals in Missouri and across the nation by U.S. News & World Report,” said Andrew Bagnall, FACHE, President and CEO of St. Luke’s. “This recognition is a powerful affirmation of the extraordinary dedication, expertise, and compassion our entire team brings to patient care each and every day. Being rated High Performing in 18 areas reflects the depth of our commitment to excellence and our unwavering focus on delivering the highest quality care. It’s an exciting milestone that celebrates the outstanding work happening across St. Luke’s—and we share this honor with every patient, caregiver, and team member who makes our mission possible.”
U.S. News evaluated more than 4,400 hospitals across 15 adult specialties and 22 procedures and conditions. Only 13% of evaluated hospitals earned a Best Hospitals designation, reflecting high standards for safety, outcomes, and quality of care.
“For more than three decades, U.S. News has been an invaluable guide for patients,” said Ben Harder, Managing Editor and Chief of Health Analysis at U.S. News. “With a ‘Best Hospital’ recognition, Americans, in consultation with their medical providers, can confidently choose a regional hospital known for providing superior care for their specific illness or condition.”
The rankings are based on objective performance measures, including risk-adjusted mortality, preventable complications, discharge-to-home rates, and nurse staffing. The methodologies rely on more than 800 million data points from patient care records nationwide. To learn more about the rankings, visit USNews.com/Best-Hospitals and follow the conversation on social media using #BestHospitals.
About St. Luke’s
St. Luke's Hospital is a nationally recognized, independent, non-profit healthcare system. Renowned for its exceptional quality and patient satisfaction, St. Luke's has consistently earned prestigious awards and accolades. The hospital holds the exclusive alliance provider status in the St. Louis market for the Cleveland Clinic Heart, Vascular, and Thoracic Institute, further solidifying its position as a leader in cardiovascular care. Since its establishment in 1866, St. Luke's has evolved into an advanced network of care. Its 493-bed hospital in Chesterfield, MO serves as a hub for its 60+ specialties and 30 locations throughout the greater St. Louis area.